What makes a good comic novel?

Nobody knows what a comic novel is. And once you start discussing it, all the fun runs out. EB White compared it to dissecting a frog (you’re left with innards and a dead frog) but I would compare it to turning all the lights on at a party: everyone looks terrible and you’ve ruined the party. [...] I think they are books that decide something is funny, as Jerry Seinfeld once defined comedy. In Moby-Dick, it’s a coin nailed to a masthead. In Vladimir Nabokov’s Pale Fire, it’s the worst best poem you’ve ever read. And yet we feel we’re getting at something the most solemn narratives aim for: an understanding of the human condition, of grief, of love, of death. All the big stuff. The comic novels I love are books that could just as easily have been tragedies. It is simply that the author has decided it’s funny. Andrew Sean Greer, The Guardian